Has the numbness and tingling issue been addressed? I am doing DD on this and haven't come across anything, but that doesn't mean it hasn't been addressed.
Brilacidin is described as a peptide mimetic. It exerts antimicrobial effects by disrupting bacterial membranes. Brilacidin belongs to a new class of antibiotics the manufacturer has dubbed defensin-mimetics. Defensin-mimetics are designed to function similarly to existing host proteins called defensins. This novel mechanism translates to broad gram-positive and gram-negative activity. Current data on brilacidin show activity against ESBLs, and the manufacturer suggests activity against methicillin-resistant Staphylococcus aureus, Enterococcus faecium and NDM-1-producing K. pneumoniae. At this time, there is insufficient data regarding brilacidin’s coverage of Pseudomonas.
In addition, brilacidin has no activity against Acinetobacter baumannii. Recently, a phase 2 trial was completed that compared brilacidin with daptomycin for the treatment of acute bacterial skin and skin structure infections. Brilacidin met all objectives of efficacy and safety in this study. Of note, 65% to 87% of patients in the phase 2 trial experienced adverse events of numbness and tingling. The significance of this is unclear at this time, and the manufacturer is moving forward with a phase 2B study of brilacidin.