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noretreat

11/11/14 9:10 AM

#77656 RE: MrW #77652

Dose related could mean at least two different things

1. the level of expression is greater with higher doses.\
2. more patients show p21 with higher doses.

or, of course, both of the above.

Here comes a gap, BTW

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oddone33320

11/11/14 9:16 AM

#77660 RE: MrW #77652

It was slightly unclear but my understanding/interpretation is that even the patients at the lowest doses were included in the "50% of patients" comment. I'd guess that if you look at the later cohorts with higher doses that you'd see a much higher % of patients with enhanced p21 activation as they indicated in the statement below:

"Initial comparisons between early and latter cohorts support Cellceutix’s expectations that p53 activation is dependent on extent of exposure to Kevetrin."