Replies to post #98180 on NanoViricides Inc (NNVC)

[drkazmd65]

That's a pretty succinct and accurate summary of the problem that NNVC faces here tryn2makamil. Same with anybody else developing a drug or treatment for Ebola/Marburg - There really is no good way to test it's effectiveness in people - without testing it in people.

And since the people who need the drugs / treatments are not particularly conveniently located, and the countries that they are in have infrastructure issues - that's an added bit of challenge.

And - although some of the potential ethical snags may be been suspended after WHO's bioethics statements of last month - some really basic safety testing (that 'first do no harm' bit) would still seem in order before an Ebolacide II would be pressed into service.

Hopefully - NNVC and the Drs. are getting this all rolling with their old USAMRIID collaborators at Ft. Detrick and this can be addressed in reasonably short order.

IF the Drs. can work the bugs out of the ligands so that they generally do not bind to the decoys that the Ebola virus produces AND more specifically target the real receptor - chances are the 'Cide is safe enough to deploy, and just might be effective if you can get it to infected people before major tissue damage has accumulated.

[r2g2]

Nice summary of where things stand.

There are obvious ifs and buts- and I would say if nothing else, EBOLA has offered a learning opportunity for the whole world- showing us where we are weak- (i.e. that more centers that can conduct testing are needed), as well as by putting pressure on companies like NNVC to get things to market- (not like there is no pressure already) hopefully stimulating some fresh thinking about the glacial process new drugs have to go through.

[Ubertino]

This Ebola drug is tough to construct but when done it will be at the apex of all the others.

Re: EbolaCide2

[e-mail]
Sep 3 (2 days ago)

to me

This is an amazing virus

Toughest one we’ve ever run into

All the other viruses we’ve developed drugs for have had straightforward solutions

I think the virus is thumbing its “nose” at us saying catch me if you can!

Only testing with multiple strains and samples of various mutated viruses will answer your question

This will be a tough hurdle for all therapeutic entities, drugs or vaccines to overcome

Constant vigilance will be required to try to stay ahead of this virus

Throwing money at the problem might not be the answer

This is clearly a case of Man vs Mother Nature

Wonder who will come out on top?


Eugene Seymour MD MPH
Chief Executive Officer
NanoViricides, Inc
[e-mail]
www.nanoviricides.com
310-486-5677
"NNVC" on the New York Stock Exchange

On Aug 31, 2014, at 9:00 AM, I wrote:

Dear Gene;

Is EbolaCide 2 immune to mutations?

Ref:

Ebola virus is mutating rapidly — say scientists

Bhavyajyoti Chilukoti August 31, 2014 at 5:48 pm

Ebola virusA recent research related to the Ebola virus disease (EVD) states that the Ebola virus is rapidly mutating, making it difficult to diagnose and treat. A study conducted on the initial patients being infected with the virus in Sierra Leone revealed more than 400 genetic modifications of the Ebola virus, which might prove detrimental for the ongoing treatment measures but also to the vaccines that are under clinical trials for future treatment of the Ebola virus. (Read: Traditional healer responsible for bringing Ebola to Sierra Leone — scientists)

The Researchers at the Broad Institute in Massachusetts and Harvard University warn that the Ebola virus is constantly undergoing mutation. The findings show that the future treatment options including vaccines as well as diagnosing of the disease will be very difficult and less effective as mutations will continue. As of now, the researchers have analysed around 99 Ebola viral genomes. Since the Ebola outbreak in West Africa in March, more than 1550 people have died of the Ebola virus disease. Earlier in August (24th), a new viral strain of the Ebola virus different from the one being observed in West Africa was detected in those from Democratic Republic of Congo, posing threat to million of lives all over the world. (Read: Latest Ebola News: Liberian Government lifts Ebola quarantine, people celebrate)

The World Health Organization has supported the use of experimental drugs (drugs which are not approved by FDA due to lack of data on human clinical trials) like ZMapp and other vaccines for treatment of Ebola infected patients. The U.N. health agency on Thursday said, ‘The Ebola outbreak will affect more than 20,000 people in West Africa and might spread to more countries, indicating a clinical emergency all over the world. It requires worldwide effort costing more than half a billion dollars to overcome the deadly Ebola outbreak.’ The WHO has announced a $490 million plan to contain the rapid spread of the Ebola virus over the next nine months due to the possibility of Ebola endemic to spread to 10 more countries, other than the four major Ebola-hit countries of West Africa namely Sierra Leone, Liberia,Guinea and Nigeria. (Read: Ebola infected monkeys said to be recovering with ZMapp)

http://www.thehealthsite.com/news/ebola-virus-is-mutating-rapidly-say-scientists/

Me