Well I would like to add that there have been many studies with thousands of pregnant women over the span of 3 years looking at cognitive function and the effect on their ms pregnancy has. Now the issue that comes to mind is , was it solely the estriol or other factors related to pregnancy? Now I'm not a neurologist and last time I did neurology was a one month rotation 3 years ago. But I would find it hard to believe that a team at ucla, one of the top medical institutions would start a study if this magnitude without taking that fact into consideration and ruling out possible confounding factors. But again it's hard to say