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Re: aslan2772 post# 24786

Monday, 02/27/2006 2:22:20 AM

Monday, February 27, 2006 2:22:20 AM

Post# of 257300
Thanks for the abstract, Aslan. Post-secretional modifications are possible with GTC/Pharming’s technology, but they are not needed for ATryn, specifically. GTC’s Dr Meade has stated that the slightly different ratio of the AT isoforms between ATryn and plasma AT favors ATryn to a small degree by improving its binding affinity to heparin. This may help and it can’t hurt, so no attempt to change the ratio of the isoforms is undertaken.

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