Manny Villafaña began his career at Fridley-based Medtronic in 1967, but left to start his own company, Cardiac Pacemakers Inc. (CPI), in St. Paul in 1972. In 1978, Eli Lilly bought CPI, which later became Guidant. Boston Scientific, based in Natick, Mass., purchased Guidant in 2006. Villafaña’s next startup, St. Jude Medical in 1976, is now one of the world’s three largest firms specializing in cardiac pacemakers, along with Medtronic and Boston Scientific. In 1987 he founded ATS Medical Inc., which Medtronic purchased in 2010 for $370 million. In 2007, he started Kips Bay Medical, which he leads today.
“Why? Why do you say it’s not fun?” Villafaña asks with a smile full of youthful exuberance. “We are doing a project right now that is potentially bigger than all of the other products I’ve done combined. We are talking about markets that are 10 times bigger than heart valve markets, four times bigger than pacemakers . . . “When a game of golf is more interesting than what I am doing,” says Villafaña, “I’ll take up golf.”