Biotech Values

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The 8-week trial in cirrhotic patients with or without ribavirin was mainly testing sofosbuvir/lediparsvir with addition of GS9669, not necessarily indicator how great 12-week of sofosbuvir/lediparsvir in cirrhotic patients were IMO.

http://clinicaltrials.gov/ct2/show/NCT01984294?term=Ledipasvir&rank=4

As of new FDC of sofosbuvir/GS5816 trials, for treatment naive with both 8-week and 12-week arms, ribavirin was added to 8-week arm but not 12-week arm later on; for treatment experienced, no 8-week arm, ribavirin was added to 12-week arm later on; as I previously noted this probably indicates ribavirin is still needed in many instances even with the new FDC.

Treatment naive:

http://clinicaltrials.gov/ct2/show/NCT01858766?term=Gs5816&rank=2

Treatment experienced:

http://clinicaltrials.gov/ct2/show/NCT01909804?term=Gs5816&rank=1