Avid Bioservices Inc (CDMO)

[goodJohnhunting]

In the past I've made mention of Microvesicles and Exosomes, and the role they play in oncogenesis, (Yes, before the Bavi video)

The most important, and widely recognized proof that PS plays a significant role in cancer, lies in that segment, IMO..

Does this mean PS is immunosuppressive or just a signal to remove the dying cell.
Bavi's literature says the opposite

Peregrine did not say the opposite, and the signal is indeed
immunosuppressive on multiple fronts, IMO. As I said, the most widely excepted and documented confirmation of PS being immunosuppressive is its association to microvesicle, and exosomes, IMO..

If you doubt me, here are a few peer review articles recognizing PS, and cMVs association..
http://cancerres.aacrjournals.org/content/66/18/9290.long
http://www.pnas.org/content/early/2011/02/18/1017667108.full.pdf

It's with little doubt that microvesicle and exosomes use the process of PS flipasse as a wormhole to escape the host cell. It's these particles that act as tumorgenic signals, and transportation of cancer proteins to stimulate a malignant environment. As cMVs (mircovesicles, exosomes) are released, tiny particle fragments of phosphatidylserine are piggybacked and released, circumventing cancer to an immune response..

I might question some things about anti-PS, but this I do not..

All the best,
John