Monday, January 20, 2014 3:33:26 PM
I am interested in how the PS receptor is able to bind PS on the cell surface when beta 2 glycoprotein is present.
PDB, PS has been known to exist "in" the bodies cells, but recently, is now known to exist on the outer plasma membrane of stressed/cancer cells only. I'm sure many Big Pharma don't like that Peregrine has these patents as part of their portfolio, and I'm sure Peregrine will limit the information as much as they possibly, legally can-- regarding Bavi patents.
Also the recent rebranding of Bavi into an immunotherapy seems like trying to get into a hot field. Before immunotherapy Bavi was supposed to work through ADCC
Again, many Big Pharma will not like the patent portfolio that exists and held by Peregrine Pharmaceuticals. The re-branding of Bavituximab is false, as its always been branded by its immuno-therapeutic properties and always had the same MOA.... though what has been changed, is the understanding of how Bavituximab actually works. It just so happens that the powers to be within Big Pharma have been pushing "cancer immunotherapy", right at the same exact time that Peregrine is proving that Bavituximab is required for that very same "cancer immunotherapy" treatment. Lucky for Peregrine, unlucky for many Big Pharma.
Opportunity for cancer patients world-wide is right around the corner and opportunity for investors is as close the many future quarterly conference calls, where analysts from all over will be saying:
"Congratulations on another great quarter Steve! My first question is regarding the price of the stock now and how you take that into consideration, at what time..if you may consider any stock splits?"
I look forward for when all those immune system / cancer immunotherapy chapters are re-written with special attention and focus to Dr. Thorpe and his contributions come to life.
On final note, wouldn't it be interesting if the "original" Big Pharma Push towards immuno-therapy was due to the thought that one day someone else would be show casing Bavituximab and not Peregrine? No such luck no more... Tustin is set for a little biotech growth pretty soon.
"Bavituximab is a first-in-class phosphatidylserine (PS)-targeting monoclonal antibody that is the cornerstone of a broad clinical
pipeline." -- Big Pharmas nightmare... unless they are fortunate enough to have The Bavi Edge!
