The numbers reflect the vast majority of patients stayed in remission despite the lowering of the dose by 15 mg. Is certainly a fantastic result given the potential 40 percent lowering of the arterial thrombotic saes which constitute the most serious saes ( my words). While venous thrombotic events are serious they are likely less problematic in terms of percentages of overall saes and also likely managed well via coumadin, plavix, and similar agents. Heart attacks, strokes, and Ischemic events resulting in limb loss all are all arterial events however, so I don't understand why this news of a 40 percent reduction in these events via a 15mg dose reduction isn't considered a fantastic possibility as discussed by the poster...it is exactly what many of us except the shorts here were praying for.