Clinical Impact of Ponatinib Dose Modification in Patients with Philadelphia Chromosome–Positive Leukemias A 15 mg reduction in average daily dose intensity is predicted to lead to ~40% reduction in the risk of arterial thrombotic events http://congressposters.ariad.com/downloads/packages/37/ASH2013_PACE_DoseMod_poster_FINAL.pdf Thanks to @chasingthealpha