Gerald might have perked up not because of a personal interest but because your comment about not being able to do a clinical study was 100% wrong and he wanted to explain to you that it if AMBS can get MANF orphan status for Wolfram's that a clinical trial will absolutely happen. Rare diseases like this always have a database of who has it. The ability to assemble willing participants won't be a problem, imho. The biggest problem AMBS will have is thge $$$ to do so. So here's hoping that AMBS can find a partner to help it get MANF into as many clinical trials as possible.