The problem with that 2M number is that it is an estimate and no one really knows the prevalence. The best estimates come from the NHANES survey, and in the 2011-12 report 0.8% of the population was positive for HCV RNA which translates to 2.3M patients. the NHANES number has varied from 0.6% to 1% over the past 16 years. However, NHANES cautions that sampling is biased towards the uninsured, the lower income, and the unemployed, which is the demographically the group with the highest rates of HCV. In other words, the NHANES number is most likely skewed towards the high end.