Biotech Values

[biomaven0]

I'm not sure if you are asking a definitional question or a medical question.

On the definition side it is quite clear - a CR requires 4 specific criteria to be met, and a PR requires a specific 3 of those 4 to be met (all except bone marrow histologic remission). A CI is quite different - it requires any one of a different set of 4 criteria to be met.

Again on the definitional side, you seem to be asking which of these might come first. Clearly a CI would come first, and then a PR and finally a CR.

On the medical side, we have now seen different treatments each achieve a different subset of the CR requirements.

In the case of Jakafi, resolution of the spleen size did not precede the achievement of other requirements for a CR or PR.

For the GERN drug we don't know yet whether the two criteria they hit in these four patients will also lead (with continued treatment) to the remaining two criteria also being met. I think that is a medical question that nobody knows the answer to yet.

I really don't think anyone here thinks Teferri is lying or even being intentionally misleading. It's more the case that people have misunderstood what he has been saying.

Peter

P.S. Not sure if this was posted previously, but here is the paper setting out the definitions of CR/PR/CI:

http://bloodjournal.hematologylibrary.org/content/108/5/1497.full.pdf