If trials had used dose titration method similar to Jakafi for MF, it would be easier to get approval because there would be more data for various doses.
jq - You and Peter were talking about dose titration well before this thing blew up. Isn't dose titration essentially what they do in phase 1? Why wouldn't they automatically try it in Phase 2 for drugs like this? It's not like it's a new unproven idea. It is common practice with Tylenol for Christ's sake.