Biotech Values

[DewDiligence]

There's no direct correlation between the TURQUOISE-1 and TURQUOISE-2 studies. Do you think TURQUOISE-1 was originally designed to stratify GT1A and GT1B cirrhotic patients?

I presume you’re asking if TURQUOISE-1 and TURQUOISE-2 were originally intended to be a matched set of trials for cirrhotic patients with GT1a and GT1b, respectively (or vice-versa). That’s possible, but it’s hard to reach such a conclusion merely from the naming of the various trials.

If the trial design were up to me, I would’ve had a phase-3 trial for cirrhotic patients that contained 4 arms in a 2x2 matrix for genotype (1a vs 1b) and duration of treatment (12w vs 24w); that would’ve accomplished the same thing as having two trials devoted to cirrhotic patients as you suggested.