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Re: DewDiligence post# 166812

Wednesday, 09/25/2013 11:25:41 AM

Wednesday, September 25, 2013 11:25:41 AM

Post# of 257268
ENTA

Although the companies have refrained from calling this regimen pan-genotypic, they have said they expect it to have efficacy in multiple genotypes



Not quite true. From Abbvie's last earnings call:

In addition to our late-stage efforts, we’re also advancing a compelling next-generation HCV program including a potent protease inhibitor, ABT-493, and a new NS5A inhibitor ABT-530. In preclinical studies, these promising assets have shown pan-genotypic activity and excellent activity against key resistant mutants



If in fact ABT-493 is truly pan-genotypic (and of course performs in the clinic), it could end up being ENTA's most valuable asset. There seem to be several pan-genotypic NS5As in development (idix, achn, gild, abbv), but i don't know of too many PIs that make this claim (idix had one back in the day that failed on safety). So it could be a rare commodity

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