Here are some EU numbers to muddle over: Costs for antimicrobial wound dressing: Per patient clinical host $1000 IRB and Ethics committees $2000 each per study Monitoring CRO - Dutch - 20 patient $45000 Monitoring CRO - Swiss - 20 patient $156000 200 patient study across 4 clinical sites would be between $700,000 and $1.75 million plus lab fees or well under $2.5 million total. Why were PYMX estimates and budget so high? They were pitching for funding for the trials plus the opreating costs for the company, IMO.