I don't think Leo should have taken the air out of the p21 announcement. That was a strange move. "we saw slight increase in p21" that's all you need to say. He made it sound VERY cautionary and glazed right over the fact that patients are responding to the treatment. In fact, I can't imagine a more boring way to share news of p21 activation and positive patient response!
I don't think we're going down but my hopes that we are blowing up have been doused a bit.