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Friday, July 12, 2013 7:45:02 PM
WIth all the excitement about anti-PD1/PDL1/CTLA4 mabs they still do not work on the majority of patients.
In addition, at ASCO there were several posters about trials combining these mabs with chemotherapy. Here are three:
1) A Phase 1 Study of Nivolumab (Anti-PD-1; BMS-936558, ONO-4538) Plus Platinum-based Doublet Chemotherapy
in Chemotherapy-naïve Non-small Cell Lung Cancer (NSCLC) Patients.
2) A Phase 1 Study of BMS-936558 Plus Sunitinib or Pazopanib in Patients With Metastatic Renal Cell Carcinoma.
3) A Phase 1 Study of BMS-936558 in Combination With Gemcitabine/Cisplatin, Pemetrexed/Cisplatin,
or Carboplatin/Paclitaxel in Patients With Treatment-Naïve, Stage IIIB/IV Non-Small Cell Lung Cancer.
"By all means let's be open-minded, but not so open-minded that our brains drop out." - Richard Dawkins
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