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Re: DewDiligence post# 163195

Saturday, 06/29/2013 2:50:17 PM

Saturday, June 29, 2013 2:50:17 PM

Post# of 257262

GILD hasn’t yet produced an oral GT1 regimen that’s even close to being competitive with the 93% SVR rate in null responders observed in ABBV’s AVIATOR study






I expect when the data reads out the results will be comparable to the ABBV basket in this subgroup. Sofo/Ledipasvir(5885) went 9/9 in a small study of nulls. The broader treatment-experienced subgroup will give a better read since patients that don't respond to interferon are becoming a throwback to an earlier time. Just like IL-28B status. Patients that fail P.I. interferon-based therapy are more likely to respond to a Nuke/NS5A combo than a combo with a second generation P.I. Just another reason to discredit the P.I. class.


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