XOMA…you said "however, I disagree that they are necessarily contradictory to the allosteric-modulation thesis" as a rebuttal against my assertion that Gev had likely shown excess risk of infection in the diabetes trial…
Again, this is a matter of degree: I don’t think Gevokizumab has sufficient excess infection risk to derail the program in uveitis if the efficacy is strong.
Nonetheless, if you believe your rebuttal-via-reference-to-MOA then you should be willing to take my wager -g-
Your proposed wager does not address a question I consider consequential in the overall scheme of things. To reiterate, I’m ok with a revelation that there is some excess infection risk in the aggregate safety database from all Gevokizumab studies as long as it doesn’t preclude regulatory approval and commercial uptake.
“The efficient-market hypothesis may be the foremost piece of B.S. ever promulgated in any area of human knowledge!”