>Lessons from ptie: be very cautious of phase III trials based on flimsy phase II's (both oxytrex and the ibs drug). This mad rush to go into phase III can be reckless.<
I would temper that by saying that it depends on how well understood the treatment pathway is. For instance, DNA jumped directly from phase-1/2 to dual pivotal trials for Lucentis because the VEGF pathway was well understood (by them).
“The efficient-market hypothesis may be the foremost piece of B.S. ever promulgated in any area of human knowledge!”