It seems Prurisol has dropped out of the mix here. My guess is that it is something more than manufacturing efficiency that is causing the delay. That said, I have no firm evidence of anything at all. I am simply speculating based on experience with other companies over several decades. It could be simply that there isn't time for it.
I think CTIX should hire another person or two to champion Prurisol.
Many of the announced supplemental actions on Kevetrin seem to be on hold pending results of Phase 1. That is as it should be, in my opinion. It seems reasonable to want at least a safety profile before starting combination studies or going after different cancers.