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Re: jq1234 post# 160558

Tuesday, 04/30/2013 9:23:48 PM

Tuesday, April 30, 2013 9:23:48 PM

Post# of 257430
VRTX JAK:

I was looking over the VX-509 data (in the PR) and while the data seem good I am curious about the safety issue(s). While the infections/death issue is dealing with a small sample I found one thing interesting in light of what GLPG likes to point out in their presentations about the advantage to targeting JAK1.

This statement seemed conveniently vague from their PR
http://investors.vrtx.com/releasedetail.cfm?ReleaseID=621143

Dose-related low-grade increases in high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol were observed in people who received VX-509.



Maybe its nothing and the those who have cholesterol issues will add a statin or something but did Vertex ever quantitatively describe this?

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