I was looking over the VX-509 data (in the PR) and while the data seem good I am curious about the safety issue(s). While the infections/death issue is dealing with a small sample I found one thing interesting in light of what GLPG likes to point out in their presentations about the advantage to targeting JAK1.
Dose-related low-grade increases in high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol were observed in people who received VX-509.
Maybe its nothing and the those who have cholesterol issues will add a statin or something but did Vertex ever quantitatively describe this?