ONXX: Yes, but only marginally; however, many investors probably think the breakthrough therapy designation is a very big deal. I agree. I was commenting more so from the market perception side. I think the palbociclib data to date have been strong enough that breakthrough therapy designation is not altogether meaningful. As a goofy aside, I think palbociclib is going to be an oft-misspelled name among investors. The allure of pablociclib is too high :-)