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Re: io_io post# 18656

Wednesday, 11/16/2005 11:25:24 PM

Wednesday, November 16, 2005 11:25:24 PM

Post# of 257302
<<<(GTOP bombed a trial a few months ago - why would this analyst be so confident now ? - disclosure: I don't own it, and don't even know what indication this discusses below)>>>

GTOP needed a p value of 0.0002 in the ttp endpoint to achieve stat sig in the first interim look (after approx 120-140 events) at their Phase III in follicular NHL. That is a very high bar to jump over. Their second interim look (approx 180-200 events) needs to show a p value of 0.0026 to achieve stat sig. There will be many more patient events for the second interim look, but that's still a high bar for look #2. The second look will probably be around July/August 2006.

This is undoubtedly a high-risk stock to be in prior to each unblinding.

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