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Post# of 252798
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Re: poorgradstudent post# 157733

Saturday, 03/02/2013 11:38:07 AM

Saturday, March 02, 2013 11:38:07 AM

Post# of 252798

I agree 520 looks fine, but the AAG stuff is overblown. But this isn't anything specific to ARRY; I've seen similar correlations many times.

Agree there are caveats and they have to prove the AAG biomarker response correlation in a prospective fashion and of course no guarantees of that. But, I am also hopeful that ARRY won't really need the AAG biomarker for 520 for success since high AAG levels only occur in 20-30% of MM patients anyways and response so far seems like it may be good enough when including these patients anyways. But, could be a nice bonus if the biomarker does pan out as I'd like to see combo data for 520+kyprolis in low AAG patients.
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