>>3)The effects of denosumab "are really dramatic," Perlmutter said. The drug is given subcutaneously just once every six months and suppresses bone turnover in hours, he said. "It's a flu shot for osteoporosis," Perlmutter said. << Yes, two shots a year and no osteoporosis? Okay, I better look into this... Don't want to have hollow bones like birds do.