The Doc has been out celebrating with friends because we found the clinical update to be absolutely validating and statically significant. A break thru ...
There was one slide which compared doses of MANF 10 mcg with MANF 3 mcg and GDNF and their effect on increasing dopamine levels in the Striatum was achieved by a factor of 10 compared to GDNF.
In addition, MANF at a dose of 10 mcg's increased the density of dopamine producing neurons in the striatum by 14 % where there was no increase from GDNF. This implies regeneration/reinnervation of dopaminergic neurons,
There were slides taken from 4 different sample sites in the striatum which showed, not only to the naked eye, but also to a sophisticated densitometer a " significant " and unexpected increase in dopamine producing terminals in the striatum.
This is the game changer for MANF and that's going head to head with a 250 million dollar drug !!!
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