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Re: errett post# 6409

Saturday, 12/29/2012 2:21:39 AM

Saturday, December 29, 2012 2:21:39 AM

Post# of 16750
If I'm doing the math/analysis correctly...

Conservatively around 500 patients should have evented based on various data I grabbed from here:

http://jjco.oxfordjournals.org/content/37/9/658.full.pdf

That's an extra 120 patients currently showing no disease progression thanks to ThermoDox.

Out of the 380 PFS events, I believe:

250 got placebo
130 got ThermoDox

Factor in that I'm forced, in part, to use data based on often small tumors only....

And we should beat 100% easy vs. 33% primary goal.

350 patients got RFA-only and 71% showing disease-progression so far vs.
350 patients got ThermoDox and 37% showing disease-progression so far

This data would suggest ThermoDox changes it from a disease with little hope to a disease with much hope, though still very dangerous, but will potentially save some lives and certain extend many many many lives much longer.

And, of course, the better it works for a tough nut to crack HCC the higher the hope/speculation for other cancers/diseases. Perhaps that's why CLSN went after one of the toughest ones first.

Raw

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