ONTY - The statistical features of the START trial have been debated on this board ad nauseam; the relevant posts can be found in the iHub archive. I feel bad for them. As strong stock board communities go they were very rational and reasonable. That said, they are the poster child for the lesson that "A trial 'going long' is a completely unreliable indicator of success.". The only other question is what alpha did they assign to the interim. Now that it is a failed trial we may never know.