Biotech Values

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The key is comparator. If it were against placebo, high G, high G plus TN would have produced similar HR IMO. But it is against investigator choice, TN patients simply don't respond to them at all, thus high G plus TN vs IC would have very high chance of success for ph3 IMO. To ensure as high chance to succeed against IC, high G need to produce better result, one way is via higher cutoff of GPNMB. This might work not only for these 3rd, 4th line patients who are very difficult to treat, but also for earlier line patients.