…if Eliquis avoids the age problem (which I think it does) and is enough better than warfarin overall (which I also think it is - if memory is not flawed) then Eliquis may be a slam dunk despite being irreversible at this point in time.
In addition to all that, Eliquis will be heavily promoted by the saleforces of two Big Pharma (PFE and BMY). I’m on record with a prediction that Eliquis will, in due course, become the biggest-selling drug of all time in peak annual sales.
“The efficient-market hypothesis may be the foremost piece of B.S. ever promulgated in any area of human knowledge!”