If a treatment-naive patient fails a nuke/NS5A combo, it's safe to say they can be retreated in the future with a nuke/P.I. without concerns over class resistance.
At worst, a patient who fails ABT’s 5-drug regimen could be retreated with an interferon/nuke-based regimen, but there will likely be other (more attractive options) too.
“The efficient-market hypothesis may be the foremost piece of B.S. ever promulgated in any area of human knowledge!”