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Re: iwfal post# 150616

Monday, 10/15/2012 4:57:46 PM

Monday, October 15, 2012 4:57:46 PM

Post# of 257253

Thanks for the clarification. Obviously that should result in lesser late relapse - but the interesting question is how much less even the lesser regimen got >90% EOT response (if I remember correctly) and yet had meaningful late relapse.

Two points:

1. The 99% (treatment-naïve) and 93% (null-responder) figures reported in ABT’s abstract today were SVR12, not EoT. (However, the SVR12 numbers were not on a strict ITT basis because data were not available for all patients at the time the abstract was submitted.)

2. The PILOT study included only treatment-naive patients, so the AVIATOR study’s 93% SVR12 in null responders does not have a comparator from PILOT.

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