Biotech Values

[exwannabe]

Yet again my pet peeve - once a drug gets reasonable efficacy with tolerable sized pills or subq injection or ... then further potency is generally of little importance.

Understand and generally agree. But is there a bit of an exception in targeted agents such as ADCs (and ECYTs small molecule equivalent)?

At a certain dose the receptors would more or less saturate. At that level, the agent may or may not be at a near optimal efficacy. The difference between this and a simple small molecule is that in the latter you can ratchet the dose to achieve the goal, in the former you can only do that to some extent.

I do agree that even in the targeted case, once the desired efficacy is reached the "we are 25x stronger" claim is nonsense.