Avid Bioservices Inc (CDMO)

[freethemice]

Using radiation does increase the amount of PS exposed. However, in the second-line NSCLC trial about 91%
of the patients had metastatic disease. Usually radiation is not used in these cases, but in earlier stages of the
disease. So future trials using radiation will most likely be in patients with stages 1-3, and then using bavi might
have the real potential of stopping transition to stage 4. There will still be a need for bavi plus chemo in the
stage 4 population. My guess is that they will use the 3 mg/kg dose in the phase 3 trial. A lower dose might work
very well with radiation in the future.