"Having personally been involved in the evaluation of over 30 Phase II trials over my career, none of which ever achieved statistical significance, including many of today's blockbuster biotech products"
I was at Genentech for 9 of his 17 years, and was in clinical development, not a dept mgr of regulatory(regulatory had no role in analysis of trial data)
I can think of 10+ ph 2 trials at genentech that reached statistical significance during his time. Why would he say that?