Ben are you shiting us here "[Any first time drug runs a higher risk of rejection."/b] Doxorubicin is an old drug approved for YEARS http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000614/ the new thing about THERMODOX is encapulation and release thru Ablation...using the Caveat in THIS SITUATION is for lack of a better description Bovine Excrement