Why don't we just wait for the results. You are correct in pointing out that 2nd line uses Doce as a chemo agent which is different than the chemo agent used in the front line trial. Dr. Thorpe pointed out a while back that Doce seemed to expose the PS on the cells to a greater extent making it a better target for bavi. Also, in a prior signal seeking trial using Doce and Bavi on metastisized Breast cancer there were very good results so yes it appears Doce is the better combo. However, for those who are interested in science and not necessarily disproving Bavi and PPHM, the use of Bavi with radiation may be better yet do to the fact that the PS is even more exposed.