Biotech Values

[DewDiligence]

Re: PPHM hazard ratio and median value

[Dew]: …the median value of the survival-probability distribution has no particular importance. The relevant metric is the hazard ratio.

[Robert Johnson]: …it seems to me the MOS we've been talking about is not a probability but historical fact.

Bob, your statement is a non sequitur.

For an explanation of why the hazard ratio rather than the median is the metric of consequence, please see #msg-13857709.

I noticed that some posters on the PPHM continue to say that the Bavituximab survival HR in NSCLC is irrelevant because the median survival is (purportedly) so impressive. In fact, HR always matters; when the FDA and other regulatory agencies evaluate a clinical variable, they look at the HR and pay little or no attention to the median value for the reason discussed in #msg-13857709. The posters on the PPHM board who are dismissing the HR as irrelevant show a fundamental misunderstanding of biostatistics, and one can safely ignore whatever they have to say on the subject.