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Re: biomaven0 post# 147081

Tuesday, 08/14/2012 8:36:07 PM

Tuesday, August 14, 2012 8:36:07 PM

Post# of 257437
I disagree about longer term treatment being more effective, I think it is just opposite. The significant but transient decrease of CRP meant the effect of inhibition of p38 alone is short lived, which is why the article talked about biologic adaptations of escape from this pathway. So to me, in addition to safety concern, either find escape pathway for potential combination treatment for longer term use, or this class of drug is only effective for very short term use.

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