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Re: biomaven0 post# 146369

Wednesday, 08/01/2012 2:20:38 AM

Wednesday, August 01, 2012 2:20:38 AM

Post# of 257391
I agree that QT issues are largely overblown.

Here, I think it's not nearly as big of an issue as have been made. Study was at 400 mg BID. I dont believe this to be a class issue with the p38's and their previous 14-day study went up to much higher doses with no QT/cardio issues; also none in their molar extraction studies.

Intracellular Signal Pathways: Potential for Therapies
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033497/

Array Phase 1 PLK/PD study
http://www.arraybiopharma.com/_documents/Publication/PubAttachment402.pdf

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