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EnVivo Pharmaceuticals Announces Statistically Significant Improvement in Cognition and Clinical Function in Phase 2b Clinical Trial in Alzheimer’s Disease
07/18/2012


WATERTOWN, Mass. – July 18, 2012 - EnVivo Pharmaceuticals, a company dedicated to developing a broad range of novel central nervous system (CNS) therapies, today announced positive results from its Phase 2b clinical trial of EVP-6124, a novel alpha-7 agonist, in patients with Alzheimer’s disease during an oral presentation at the Alzheimer's Association International Conference 2012 (AAIC) being held in Vancouver, British Columbia. The six-month, double-blind Phase 2b clinical trial evaluated EVP-6124 against placebo in patients with mild to moderate Alzheimer’s disease. The EVP-6124 2.0 mg dose met both of the trial’s primary endpoints with statistically significant positive effects on cognition (p=0.0189), as measured by the Alzheimer's Disease Assessment Scale-Cognitive subscale-13 (ADAS-Cog-13) and clinical function (p=0.0253) as measured by the Clinical Dementia Rating Scale Sum of Boxes (CDR-SB). The data also showed statistically significant results across secondary endpoints of other cognitive and clinical measures. Importantly, EVP-6124 was generally safe and well-tolerated over the trial’s six-month dosing period. Based on the Phase 2b trial results, EnVivo will continue to advance EVP-6124 and plans to initiate a Phase 3 clinical trial in Alzheimer’s disease in 2013.

http://www.envivopharma.com/news-item.php?id=40