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Re: DewDiligence post# 145672

Wednesday, 07/18/2012 11:06:17 AM

Wednesday, July 18, 2012 11:06:17 AM

Post# of 257257

The U-shaped dose-response curve doesn’t bother me as much in this instance as it normally would because the MoA of Gammagard in AD is very poorly understood



Two comments:

a) I think the base rate of drugs with u-shaped dose response vs more traditional monotonic dose response is that u-shaped is pretty rare.

b) That said, my impression is that the immune system is more likely to have odd dose response curves. But it is only an 'impression'.

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