While I don't think the CRL is the end of the story for Xarelto in ACS…
It may be the end of the story for Xarelto in ACS per se. My guess is that JNJ will decide to refocus on the PCI sub-indication of ACS, which is the subject of a separate NDA submission made in May 2012.
“The efficient-market hypothesis may be the foremost piece of B.S. ever promulgated in any area of human knowledge!”