Great discussion jq and Clark! Any guess why the study powered at an alpha of 0.01? Could there be an ace in the sleeves that some alpha were April ori allocated to Met high subgroup? http://files.shareholder.com/downloads/ARQL/0x0x475367/d057ce4f-843b-4b92-824a-3f5a387ae42e/Phase%203%20NSCLC%20in%20progress%20ASCO%2011.pdf