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Re: iwfal post# 142678

Friday, 05/25/2012 10:08:31 PM

Friday, May 25, 2012 10:08:31 PM

Post# of 257430

My guess is that, unlike HG/TN, ultra high G does NOT show meaningfully increased efficacy over high G (which was almost entirely driven by TN/HG subgroup anyway).

Perhaps there could be a diminishing rate of effect as they move towards higher levels of GPNMB expression. I'd be more concerned obviously if ultra high G 011 arm doesn't show efficacy compared to IC group. Even if it shows similar efficacy to the high G group, as long as 011 still meaningfully beats the IC arm, I think that would bode well for CLDX.

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