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Re: biotech jim post# 141508

Monday, 05/07/2012 11:51:59 PM

Monday, May 07, 2012 11:51:59 PM

Post# of 257257

I posted here some of my comments after a quick read of the PFE tofacitinib briefing documents.

www.siliconinvestor.com/readmsg.aspx?msgid=28130345

Anyone interested in current or future RA drugs would do themselves a great service by reading these documents
.

Question on the potential malignancy risk in man. Do you think this potential concern is something specific to JAK inhibitors or is the potential concern broader? I ask because I'm curious if RIGL's fostamatinib, which is a Syk inhibitor, might not share this same risk, or at least the same degree of risk, and could have a potential advantage on this point.

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